Inverse has an article that describes more of the growing realization that there are a number of problems with science as it is now practiced in the age of "if it doesn't sell, it doesn't sail."
Not only has "reproducible" not been taken as seriously as it should have been (reproducing the work of others doesn't get you the publishing creds that original work does), the whole universe of "publish or perish," and the fact that a few publications dominate this arena, makes for a formula that emphasizes the "sexy" over the long term foundation building that less sexy can yield. And the pressure to keep on publishing new "finds" can lead to the taking of shortcuts (as in much smaller sampling), or the temptation to fudge results.
The title of the article says it all, of course, especially as it relates to Capitalism, though I too believe we shouldn't give up. We just have to realize that fundamental change is required.
But that doesn't mean we should give up.